L-Tyrosine
Cas No. 60-18-4
What is L-Tyrosine?
L-Tyrosine, or tyrosine (Tyr), is a protein amino acid synthesized from phenylalanine. Another term for this compound is 4-Hydroxyphenylalanine. It acts as an intracellular neurotransmitter, and is also involved in the synthesis of dopamine. Tyrosine is used as a supplement to help assimilate information, reduce fatigue and improve physical fitness. Natural sources of this compound in the diet are m. in. Walnuts, tuna, Parmesan cheese, beef, pumpkin seeds or pork.
Use of L-Tyrosine
Tyrosine is an endogenous amino acid, meaning that it is synthesized in the human body. L-tyrosine is the naturally occurring form of this amino acid. Tyrosine is used as a preparation to improve brain function. It is a supplement ideal for people who lack energy for action and motivation. It can support cognitive function, reduce chronic fatigue and have a beneficial effect on mental well-being, similar to ALCAR. It exhibits adaptogenic effects, so it is ideal for people under stress. It increases the body’s tolerance to stress, and makes it easier to fall asleep.
Mechanism of action
Tyrosine is an amino acid that is a precursor to such neurotransmitters as epinephrine, norepinephrine and dopamine. As a result, it can increase the body’s resistance to stress, boost energy and increase motivation levels. The function of tyrosine in the body is also involved in the synthesis of thyroid hormones, as well as melanin, the skin pigment. Like many other amino acids, L-Tyrosine participates in the process of collagen synthesis, thus strengthening the structure of connective tissue.
Dosage of L-Tyrosine
Tyrosine should be taken at a dose of 100 mg/ kg m. c. This daily dose should be taken in 2-3 doses throughout the day. The product is best taken no later than 30 minutes before a meal. The combination of L-Tyrosine with vitamin C and folic acid improves the metabolic processes of this amino acid. In turn, supplementation combined with caffeine or EGCG enhances the beneficial effects of tyrosine on brain function.
References:
- Nakashima A, et al, Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines, J Neural Transm., 2009; https://pubmed.ncbi.nlm.nih.gov/19396395/
- Daubner SC, Le T, Wang S, Tyrosine hydroxylase and regulation of dopamine synthesis, Arch Biochem Biophys, 2011; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065393/
- Hase A, Jung SE, aan het Rot M. Behavioral and cognitive effects of tyrosine intake in healthy human adults. Pharmacol Biochem Behav. 2015 Jun;133:1-6; https://pubmed.ncbi.nlm.nih.gov/25797188/
- Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review. J Psychiatr Res. 2015 Nov;70:50-7; https://pubmed.ncbi.nlm.nih.gov/26424423/
