L-Phenylalanine
Cas No.: 63-91-2
What is L-Phenylalanine?
Phenylalanine is an essential amino acid that is not synthesized in the body and must be supplied externally. L-Phenylethylalanine is the natural form of this amino acid, so it is perfectly absorbed by the body. Other names used to describe phenylalanine are 2-amino-3-phenylpropionic acid, 2-amino-3-propanoic acid, Phe, F.
Natural dietary sources of phenylalanine include m. in. Milk and eggs, meat, fish. Phenylalanine is essential for the proper functioning of the body. Inborn disorders of phenylalanine metabolism lead to the development of phenylketonuria, which can result in the development of irreversible damage within the nervous system. L-Phenylalanine is part of the body’s structural proteins. In addition, it participates in the synthesis of many neurotransmitters, as does Bromantan.
Uses of L-Phenylalanine
Phenylalanine is a formula used to improve cognitive function and support brain function. The product improves memory and concentration, so you can reach for it during periods of increased mental effort. It fosters greater motivation, willingness to act. Facilitates the body’s adaptation to stressful conditions. Has a beneficial effect on stabilization Mood and relieves anxiety. The benefit of the supplement will also be felt by physically active people.
Mechanism of action
The compound crosses the blood-brain barrier. Phenylalanine is involved in the synthesis of such neurotransmitters as epinephrine, norepinephrine and dopamine. Via the aforementioned transmitters, L-Phenylalanine can increase the efficiency of neurotransmission processes in the brain. As a result, it facilitates learning processes, as well as the body’s adaptation to stressful conditions. In people with migraines, it can relieve intractable headaches.
Increased levels of catecholamines in the body (adrenaline and norepinephrine) are accompanied by an increase in energy and motivation, so use of the product is accompanied by better physical performance during training.
Dosage of L-Phenylalanine
The recommended dosage of L-phenylalanine is 200 to 1,500 mg per day. The most common is 500 mg taken three times a day. To maximize the beneficial effects of L-Phenylaalanine on the body, perhaps combine the supplement with rhodiola rosea, caffeine, EGCG or L-tyrosine.
References:
- Montgomery AJ, McTavish SF, Cowen PJ, Grasby P.M.,Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [(11)C]raclopride PET study. Am J Psychiatry, 2003; https://pubmed.ncbi.nlm.nih.gov/14514507/
- ten Hoedt AE, de Sonneville LM, Francois B, ter Horst NM, Janssen MC, Rubio-Gozalbo ME, Wijburg FA, Hollak CE, Bosch AM. High phenylalanine levels directly affect mood and sustained attention in adults with phenylketonuria: a randomized, double-blind, placebo-controlled, crossover trial. J Inherit Metab Dis. 2011 Feb;34(1):165-71; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026661/
- Romani C, Palermo L, MacDonald A, Limback E, Hall SK, Geberhiwot T. The impact of phenylalanine levels on cognitive outcomes in adults with phenylketonuria: Effects across tasks and developmental stages. Neuropsychology. 2017 Mar;31(3):242-254; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331922/
- Kaufman S. A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3160-4; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC15912/
