J147
Cas No.: 1146963-51-0
J147 – what is it?
J147 (2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide) is a formulation invented in 2011. This compound is derived from curcumin, the active ingredient in turmeric. Unlike curcumin, it can cross the blood-brain barrier. It is also referred to as N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N’-[(E)-(3-methoxyphenyl)methylene]acetohydrazide. Research on the drug’s use focuses primarily on its contribution to the treatment of Alzheimer’s disease. But this is not the only use of the product. Protects brain cells from progressive neurodegenerative processes. It can support memory and facilitate learning, as can Fl Modafinil. This means that it differs from other nootropics in both neuroprotective and neurogenic activity, and slows down the aging process.
Use of curcumin derivative
The product can be used by elderly people with cognitive impairment that progresses with age. In addition, the product is credited with anti-aging properties. By way of extending mitochondrial lifespan and reducing oxidative stress, the formula can slow down the body’s aging process. Younger people, on the other hand, may experience the benefits of better concentration and an easier learning process.
J147 can help treat Alzheimer’s disease. In those affected by the disease, the product may allow the progression of the disease to slow down. In addition, it improves cognitive function and memory. Another valuable property of the product is the alleviation of anxiety and depression. This profile of action is also demonstrated by Coluracetam.
Mechanism of action J147
J147 increases levels of such neurotransmitters as NGF and BDNF. As a result, it has a positive effect on learning processes, cognitive function and memory. It affects ATP synthase, the enzyme responsible for increasing the level of ATP, a high-energy compound in the cell. Thus, it normalizes ATP levels and reduces the formation of oxidative stress, i.e. excessive accumulation of free radicals that can accelerate the aging process.
J147 dosage
It is recommended to take J147 at a dose of 5 to 30 mg. The most common dosage is in the range of 10-20 mg per day. You can start by taking a smaller dose, and if it is well tolerated by the body – increase the amount taken per day.
References:
- Prior M, Dargusch R, Ehren JL, Chiruta C, Schubert D. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706879/
- Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor. Neuropharmacology. 2018 Jun;135:506-513; https://pubmed.ncbi.nlm.nih.gov/29626566/
- Emmanuel IA, Olotu FA, Agoni C, Soliman MES. Deciphering the ‘Elixir of Life’: Dynamic Perspectives into the Allosteric Modulation of Mitochondrial ATP Synthase by J147, a Novel Drug in the Treatment of Alzheimer’s Disease. Chem Biodivers. 2019 Jun;16(6):e1900085; https://pubmed.ncbi.nlm.nih.gov/30990952/
