Forskolin
Cas No.: 66575-29-9
What is forskolin?
Forskolin (isoforskolin, coleonol) is an active compound extracted from Indian nettle, a plant that grows in subtropical climates. Other terms forskolin found in the professional medical literature are: Coleus forskohlii, 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin, Plectranthus barbatus, Coleus barbatus, Indian coleus, falso boldo, boldo brasiliero, boldo-de-jardim, Indian sage. Forksolin is also recognized by its English name Forksolin.
Formulations containing forskolin are most commonly used to promote weight loss. The benefits of supplementation can also be felt by physically active and mentally active people. The effects of forskolin on the body also include support for the cardiovascular system and liver. And men will appreciate the compound for its effects on testosterone levels.
Uses of forskolin
Indian nettle extract can promote the loss of body fat . In clinical trials, it was shown that after 12 weeks of using forskolin at a dose of 250 mg per day, it allowed greater weight loss than in the placebo group. Fat burning can also be stimulated by EPH preparation.
Forskolin shows a very beneficial effect on the nervous system. Increased levels of the cAMP compound are accompanied by the phenomenon of prolonged synaptic excitation. This makes learning more effective. By activating dopamine receptors, forskolin can help treat Parkinson’s disease. Reversing the possibility of reversing the harmful effects of beta amyloid, on the other hand, may aid in the treatment of Alzheimer’s disease.
Forskolin increases testosterone levels in men, in addition, it has a beneficial effect on potency, extending the duration of erections. By increasing insulin levels in the body, the compound helps normalize blood glucose levels. Forskolin is recommended for asthma sufferers because it has a bronchodilator effect on the bronchi. The beneficial effects on the cardiovascular system boil down to normalization of blood pressure, acceleration of heart rate and anticoagulant action.
Mechanism of action
The effect of forskolin on the body comes down to an increase in the level of cAMP, or cyclic adenosine monophosphate. It is a compound responsible for transmitting signals within cells. cAMP can increase basal metabolism. Decreased levels of this compound have been shown in the course of conditions such as obesity, hypertension and other cardiovascular diseases, psoriasis and asthma. Since forskolin increases cAMP levels, it may find use as an effective adjunct therapy for these conditions.
Forskolin – dosage
The recommended dosage of forskolin is 250 mg of the extract standardized to contain 10% forskolin, taken twice a day. Synergistic effects and enhancement of supplementation effects are provided by combining forskolin with caffeine, EGCG or Chinese citronella.
References:
- Loftus HL, Astell KJ, Mathai ML, Su XQ. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015 Nov 17;7(11):9508-22; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663611/
- Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 2005 Aug;13(8):1335-43; https://pubmed.ncbi.nlm.nih.gov/16129715/
- Hermansen K. Forskolin, an activator of adenylate cyclase, stimulates pancreatic insulin, glucagon, and somatostatin release in the dog: studies in vitro. Endocrinology. 1985 Jun;116(6):2251-8; https://pubmed.ncbi.nlm.nih.gov/2581771/
- Wanderoy M.H., Westlind-Danielsson A. Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors. Cell Mol Neurobiol. 1997; https://pubmed.ncbi.nlm.nih.gov/9353595/
