Hexahydrocannabinol reaches an analytical laboratory as a reference material rather than as a bulk chemical, and the paperwork around it carries more decisions than the container itself. The identity block below collects the data that stay constant between suppliers; the sections that follow deal with the two entries that do not, namely the ratio of epimers and the format in which the standard is delivered.
| Entry | Data |
|---|---|
| Abbreviation in common use | HHC |
| Registry number, 9(S) epimer | 36403-91-5 |
| Registry number, 9(R) epimer | 36403-90-4 |
| Molecular formula | C21H32O2 |
| Formula weight | 316.5 |
| Structural class | Tricyclic cannabinoid with a pyran bridge and a saturated six-membered carbocycle |
| Origin of the scaffold | Hydrogenation of the carbon-carbon double bond present in the unsaturated cannabinoid precursor |
| Reference standard purity | Analytical standards are offered at a stated minimum of 98 per cent |
| Common delivery format | Neat material or a solution standard, for example 10 mg/ml in acetonitrile |
| Intended context | Method calibration, retention matching and quantitative determination |
Why the scaffold is described as saturated
The tricyclic core consists of a resorcinol-derived aromatic ring bearing a pentyl chain, a pyran ring closed by an oxygen bridge and carrying two methyl groups on one carbon, and a third ring that in this compound is a plain cyclohexane with a methyl substituent. In the unsaturated cannabinoids that third ring holds a trisubstituted double bond, and it is precisely that bond which hydrogenation removes. The formula difference amounts to two hydrogen atoms, while the practical difference is the disappearance of an allylic position that is a common starting point for oxidation and for acid-promoted rearrangement.
What remains reactive is the free phenolic hydroxyl on the aromatic ring. Phenols oxidise to coloured products, so darkening of a stored standard is a signal worth recording rather than ignoring. The long alkyl chain makes the material strongly lipophilic, which in dilute solution shows up as adsorption on plastic surfaces and as a measured concentration below the nominal one. Zobacz również pozycja katalogowa odczynnika: Bromantan/Ladasten/Bromantane 1000mg, 99% zawartoś.
The epimer ratio is a specification item, not a detail
Hydrogenation creates a new stereocentre at carbon nine, and the two resulting epimers are separate substances with separate registry numbers. They share a molecular formula, a formula weight and, for practical purposes, a mass spectrum. A certificate that names only the abbreviation therefore identifies a family rather than a substance, and any quantitative result traced to such a standard inherits that ambiguity.
The ratio in a given lot depends on how the material was made, so it has to be measured rather than assumed. Where a method is used to support a numerical claim, the epimer composition of the calibrant belongs in the method file next to the retention data.
Separating the material chromatographically
Ordinary reversed-phase conditions may resolve the two epimers into closely spaced peaks, merge them into one broadened signal, or place one of them under an unrelated component. All three outcomes look plausible on a chromatogram, and only a run against characterised standards distinguishes them. Where the epimers must be reported individually, the separation is selected for that purpose and demonstrated with a resolution figure obtained on the actual system.
Detection adds a second consideration. Because the epimers share a formula, mass-selective detection alone cannot assign them, and the assignment rests on retention order established with reference materials of known configuration.
Receiving and documenting a batch
The steps below cover what a laboratory records before the standard enters routine use.
- Registry number for the epimer actually supplied, copied from the certificate rather than from the catalogue page.
- Epimer composition, or a statement that a single epimer was supplied.
- Delivery format, solvent and nominal concentration for solution standards.
- Storage temperature specified for the lot, together with the date the container was first opened.
- Container material and closure type, since lipophilic solutions interact with plastic surfaces.
Registry numbers, formula and formula weight are fixed reference data and may be carried between lots. Epimer composition, purity and delivery format belong to the individual consignment, and only the current certificate settles them. Zobacz również ten sam materiał w innej gramaturze: Phenylpiracetam / Phenylpiracetam, Purity ≥ 99%, 1.
Pokrewne odczynniki laboratoryjne
- Phenylpiracetam / Phenylpiracetam, Purity ≥ 99%, 1000mg
- Bromantan/Ladasten/Bromantane 1000mg, 99% zawartości Bromantanu w opak
- Forskolina / Forksolin. Czystość ≥99% 1000mg.
- L-DOPA ≥ 99%. Czysta substancja chemiczna bez wypełniaczy!
Badania indeksowane w PubMed
Badania na zwierzętach i in vitro indeksowane w bazie PubMed; strona nie zawiera wskazówek dotyczących stosowania u ludzi.
- Labadie M Hexahydrocannabinol poisoning reported to French poison centres 2024, Clinical toxicology (Philadelphia, Pa.). PMID 38426845
- Schirmer W Identification of human hexahydrocannabinol metabolites in urine 2023, European journal of mass spectrometry (Chich. PMID 37709263
- Tanaka R Identification of hexahydrocannabinol (HHC), dihydro-iso-tetrahydrocannabinol (dihydro-iso-THC) and hexahydrocannabiphorol (HHCP) in electronic cigarette cartridge products 2024, Forensic toxicology. PMID 37365398
- Šíchová K Hexahydrocannabinol: pharmacokinetics, systemic toxicity, and acute behavioral effects in Wistar rats 2025, The international journal of neuropsychophar. PMID 40643195
Status materiału
Materiał nie jest przeznaczony do użycia przez ludzi. Nie przewidziano dla niego zastosowań weterynaryjnych. Jest to wysokiej czystości produkt laboratoryjny do prac badawczych z użyciem HPLC i GC-MS. Poza kategorią produktów leczniczych i spożywczych.
