Description
Bench notes for a diacylpiperazine solid supplied in gram quantities.
Identity
The label data are the fixed points; everything else is inference.
- Registry number 314728-85-3, also catalogued under the laboratory code DM-235.
- Empirical formula C14H18N2O2, formula mass 246.30 g/mol.
- Skeleton: a piperazine ring acylated on both nitrogen atoms — an aromatic benzoyl group on one, a short aliphatic propanoyl chain on the other.
- The atom count of that arrangement matches the confirmed formula exactly, which is the first consistency check worth running on any certificate.
What the two amide bonds imply
Both ring nitrogen atoms are amidic, so neither is available as an ordinary base.
- Amide linkages resist hydrolysis near neutral pH but yield to prolonged heating in strong acid or strong alkali.
- Loss of either acyl group leaves a mono-acylated piperazine that is markedly more polar than the parent solid.
- That polarity gap is exactly what makes reversed-phase chromatography a sensitive test for decomposition.
- No stereocentre is present, so chiral analysis has no place in the identity work.
Storage
Treat the container as a dry-goods item with a written history.
- Cool, dry, dark; tightly closed and returned to storage promptly after weighing.
- Segregate from strong acids, strong bases and strong oxidising agents.
- Let a refrigerated container reach ambient temperature before opening, so moisture does not condense on the powder.
- Log every opening; the number of openings predicts water uptake better than the calendar does.
Analytical checks worth running
Two orthogonal methods settle identity faster than one exhaustive method.
- Mass spectrometry for a molecular ion consistent with the formula above.
- Proton NMR, where the aromatic multiplet, the piperazine envelope and the ethyl fragment of the propanoyl group are separately visible.
- Chromatographic purity compared against the assay stated on the certificate of analysis.
- Water determination, since a damp batch reports a falsely low assay by mass.
Documentation
A batch without paperwork is stock, not a characterised reagent.
- Certificate of analysis tied to the batch identifier printed on the vial.
- Safety data sheet held with the inventory record instead of a drawer.
- Internal log covering receipt, first opening and remaining quantity.
Inne pozycje katalogowe
- Phénylpiracétam/Phénylpiracétam, Pureté ≥ 99%, 1000mg
- L-Tyrosin / L-Tyrosin /Tyrosin Reinheit ≥ 99% 1000mg
- Mebicar / Mebicar / Temgicoluril – 30x capsules 100mg. Purity ≥ 99%
- Löwenmähne / Igelsopran / Hericium Erinaceus < 10g 99% Soprano Pulv
Literatura przedmiotu
Badania na zwierzętach i in vitro indeksowane w bazie PubMed; strona nie zawiera wskazówek dotyczących stosowania u ludzi.
- Moriguchi S Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice 2013, Behavioural brain research. PMID 23295391
- Martini E Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers 2009, Bioorganic & medicinal chemistry. PMID 19786353
- Moriguchi S Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor 2013, Hippocampus. PMID 23733502
- Agha KA Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening 2022, Journal of enzyme inhibition and medicinal c. PMID 35484855
Zakres stosowania. Nie jest to substancja do użycia u ludzi. Materiał nie jest produktem weterynaryjnym. To odczynnik laboratoryjny wysokiej czystości, przeznaczony do badań analitycznych metodami HPLC i GC-MS. Nie jest produktem leczniczym ani środkiem spożywczym.
