Description
| Parameter | Value |
|---|---|
| Molecular formula | C8H14N4O2 |
| Formula weight | 198.22 g/mol |
| CAS registry number | 10095-06-4 |
| Systematic name | Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione |
| Synonyms | Mebikar, Temgicoluril, tetramethylglycoluril |
| Scaffold | Bicyclic glycoluril, a fused bis-ureide, fully N-methylated |
| Ionisable groups | None of practical relevance in an ordinary buffer window |
| Presentation | Pre-portioned units of 100 mg, per supplier specification |
Reading the scaffold
Glycoluril is two urea units fused into a rigid bicyclic cage, and this compound is the derivative in which all four ring nitrogens carry a methyl group. That substitution pattern removes every nitrogen-hydrogen donor from the molecule. The consequence is chemical rather than cosmetic: hydrogen-bond donation disappears, the tight crystal packing that makes unsubstituted glycoluril stubbornly insoluble is disrupted, and the methylated cage gains solubility in water and in polar organic solvents that the parent scaffold does not possess.
Stability of a fully substituted bis-ureide
Cyclic ureas rank among the more hydrolytically robust nitrogen functions in organic chemistry, and a doubly fused, fully methylated one is more robust still. Ring opening calls for forcing acid or base at elevated temperature, not the conditions of ordinary storage or of an aqueous work-up. The realistic failure modes for this material are therefore physical: moisture pickup leading to caking, and cross-contamination carried in on a shared spatula. See also our reagent-grade material: Mebicar / Mebicar / Temgicoluril – 30x capsules 10.
Analytical handling
The molecule has no aromatic ring and no strong chromophore, so ultraviolet detection at the usual wavelengths is a poor tool for purity work. Assay stands on firmer ground with mass spectrometry, with a universal detector such as charged aerosol detection, or with quantitative proton nuclear magnetic resonance against a certified internal standard. The last is convenient here because the four N-methyl groups have no neighbouring protons and appear as clean singlets, which makes identity confirmation a matter of minutes. See also our laboratory reagent: Bleu de méthylène / BLEU DE MÉTHYLÈNE. Pureté ≥ 99.
Storage checklist
- Keep the original sealed packaging; renew the desiccant rather than assume it is still active.
- Cool, dry and out of direct light — ambient laboratory conditions suffice where humidity is controlled.
- Equilibrate the container to room temperature before breaking the seal.
- Dedicate one spatula per lot; a fully substituted ureide is hard to spot as a contaminant by ultraviolet.
- Record lot, opening date and remaining quantity at every withdrawal.
Other catalogue items
- Bleu de méthylène / BLEU DE MÉTHYLÈNE. Pureté ≥ 99,99% 1000mg.
- Mebicar / Mebicar / Temgicoluril – 30x capsules 100mg. Pureté ≥ 99%
- Methylenblau / METHYLENBLAU. Reinheit ≥ 99,99% 1000mg.
- VIAGRA / Tadalafil Purity ≥ 99% 1000mg.
Indexed publications
Animal and in vitro studies indexed in PubMed; no human-use guidance is provided here.
- Kim CY Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice 2018, Neuroimmunomodulation. PMID 29920498
- Val'dman AV [Characteristics of the psychotropic spectrum of action of mebicar] 1980, Biulleten' eksperimental'noi biologii i medi. PMID 6104993
- Kamburg RA [An analysis of the cardiovascular reactions due to mebikar] 1990, Farmakologiia i toksikologiia. PMID 2253745
Material status. The material must not be used in humans. No veterinary applications are provided for. Intended use: laboratory work and analytical determination by HPLC and GC-MS. It is neither a medicinal product nor a foodstuff.
