Description
A specification sheet for choline alfoscerate is short, and every line on it constrains something physical at the bench. The table pairs each entry with the operational consequence that follows from it. See also our laboratory reagent: FL-MODAFINIL, 99% Czystości, 1000MG OR 1GRAM.
| Parameter | Value | What it forces in laboratory practice |
|---|---|---|
| Empirical formula | C8H20NO6P | One phosphorus atom per molecule, which makes phosphorus NMR both an identity tool and a purity indicator. |
| Formula mass | 257.22 g/mol | The conversion factor between a weighed portion and molar concentration; a damp weighing distorts it immediately. |
| Registry number | 28319-77-9 | The identifier tying the container to its safety data sheet and to the correct line in a chemical inventory. |
| Structural class | Glycerophosphocholine: a phosphodiester joining glycerol to a quaternary ammonium alcohol | Two P-O ester linkages, both responsive to strongly acidic and strongly alkaline surroundings. |
| Physical form | White waxy solid | Not free-flowing; transfer with a spatula, expect adhesion to glass and plastic, and allow extra time for quantitative transfer. |
| Water behaviour | Miscible with water | Aqueous stocks are trivial to prepare; the same property means the solid pulls moisture out of room air. |
| Alcohols | Soluble in methanol and ethanol | Alcoholic media are available for recrystallisation trials and for sample preparation ahead of chromatography. |
| Non-polar solvents | Insoluble in chloroform and diethyl ether | Partition between water and a non-polar phase leaves the material in the aqueous layer: useful for clean-up, useless for extraction. |
| Ionic character | Permanent cationic ammonium centre with an anionic phosphate | Retention on plain reversed-phase columns is poor, so hydrophilic interaction or ion-pairing is normally required. |
The waxy, hygroscopic character causes most of the trouble in day-to-day work. Mass drifts upward on an open balance because water is being adsorbed while the reading is taken, so the honest procedure is a rapid weighing in a dry enclosure, with the container brought to ambient temperature beforehand.
Hydrolysis of the phosphodiester is the slow failure mode. It needs neither air nor light, only water together with time and a pH far from neutral; the fragments are more polar than the parent and appear early in a polar separation. A batch kept cold, sealed and over desiccant ages far more slowly than one left in a warm cupboard. See also our reagent-grade material: Aniracetam ≥ 99%. Czysta substancja chemiczna bez .
Purity figures refer to the analytical method printed beside them. An assay by titration and an assay by phosphorus NMR answer slightly different questions, and only the second distinguishes an intact diester from its cleavage fragments. Where a certificate stays silent about the method, treat the number as unverified rather than as a property of the material.
Finally, the registry number deserves a second look at goods-in. Related glycerophosphocholine entries and salt forms circulate under similar names, and a mismatch between the label and the inventory record is easier to resolve on the loading bay than three months later in the middle of an assignment.
Other catalogue items
- Aniracetam ≥ 99%. Czysta substancja chemiczna bez wypełniaczy 1000mg.
- FL-MODAFINIL, 99% Czystości, 1000MG OR 1GRAM
- Mebicar / Mebicar / Temgicoluril – 30x cápsulas 100mg. Pureza ≥ 99%
- ALCAR / Acetyl-L-Carnitine – Purity ≥ 99% net weight 1000mg.
Selected literature
Animal and in vitro studies indexed in PubMed; no human-use guidance is provided here.
- Kolykhalov IV [Clinical and immunological effects of choline alfoscerate in the treatment of amnestic type Mild Cognitive Impairment] 2022, Zhurnal nevrologii i psikhiatrii imeni S.S. . PMID 36412158
- Li J L-Alpha-Glycerylphosphorylcholine (L-α-GPC): A Comprehensive Review of Its Preparation Techniques and Versatile Biological Effects 2025, Journal of food science. PMID 40556032
- Sun L Validated quantitative (31)P NMR spectroscopy for positional isomeric impurity determination in L-α-glycerylphosphorylcholine (L-α-GPC) 2022, Journal of pharmaceutical and biomedical ana. PMID 36179504
- Lee HJ Potential Risk of Choline Alfoscerate on Isoflurane-Induced Toxicity in Primary Human Astrocytes 2024, Journal of Korean Neurosurgical Society. PMID 37859347
Intended use
The material must not be used in humans. No veterinary applications are provided for. The material serves solely as a standard and reagent in HPLC and GC-MS analysis. It is neither a medicinal product nor a foodstuff.
