{"id":829,"date":"2022-09-16T10:31:29","date_gmt":"2022-09-16T10:31:29","guid":{"rendered":"https:\/\/flmodafinil.pl\/sunifiram-mecanisme-daction-et-posologie\/"},"modified":"2022-10-29T17:28:45","modified_gmt":"2022-10-29T17:28:45","slug":"sunifiram-mecanisme-daction-et-posologie","status":"publish","type":"post","link":"https:\/\/flmodafinil.pl\/fr\/sunifiram-mecanisme-daction-et-posologie\/","title":{"rendered":"Sunifiram – m\u00e9canisme d’action et posologie"},"content":{"rendered":"\n

Sunifiram<\/p>\n\n

N\u00b0 CAS : 314728-85-3<\/p>\n\n

Qu’est-ce que le sunifiram ?<\/h2>\n\n

Le sunifiram ( 1-benzoyl-4-propanoylpiperazine) est un d\u00e9riv\u00e9 synth\u00e9tique du pirac\u00e9tam, un m\u00e9dicament nootrope. D’autres noms pour la pr\u00e9paration incluent ampakine, DM-235.<\/p>\n\n

Il est consid\u00e9r\u00e9 comme l’une des formulations nootropiques les plus puissantes, avec un excellent soutien de la fonction cognitive et une augmentation des niveaux d’\u00e9nergie. Le modafinil<\/a>, par exemple, a un effet similaire. En outre, la formule peut stimuler le m\u00e9tabolisme des cellules nerveuses du cerveau, facilitant ainsi l’apprentissage. Les effets possibles du produit comprennent \u00e9galement la stabilisation de l’humeur et la r\u00e9duction du besoin de sommeil.<\/p>\n\n

Utilisation du sunifiram<\/h2>\n\n

\u00c0 ce jour, il n’existe pas d’\u00e9tudes cliniques fiables sur les effets du sunifiram sur le corps humain. Cependant, les r\u00e9sultats des \u00e9tudes sur les animaux sont tr\u00e8s prometteurs. La formule est connue pour \u00eatre excellente pour le soutien de la m\u00e9moire, et ce m\u00eame en cas de troubles de la m\u00e9moire induits chirurgicalement ou pharmacologiquement. En outre, il a \u00e9t\u00e9 d\u00e9montr\u00e9 que le sunifiram a un effet b\u00e9n\u00e9fique sur l’apprentissage et la m\u00e9moire, en augmentant la vitesse \u00e0 laquelle les informations sont absorb\u00e9es et trait\u00e9es.<\/p>\n\n

En am\u00e9liorant les capacit\u00e9s perceptives, la formule aiguise la sensibilit\u00e9 \u00e0 une vari\u00e9t\u00e9 de stimuli externes, y compris les stimuli visuels et auditifs. \u00c0 son tour, la perception accrue des stimuli tactiles peut s’accompagner d’une plus grande excitation physique et d’une augmentation de la libido.<\/p>\n\n

Certaines \u00e9tudes sugg\u00e8rent que le sunifiram<\/a> peut avoir des effets analg\u00e9siques mod\u00e9r\u00e9s, ainsi que r\u00e9duire la fatigue et le besoin de sommeil.<\/p>\n\n

M\u00e9canisme d’action du sunifiram<\/h2>\n\n

Le m\u00e9canisme d’action de la pr\u00e9paration n’a pas \u00e9t\u00e9 enti\u00e8rement \u00e9lucid\u00e9. On sait avec certitude qu’il affecte l’activit\u00e9 des r\u00e9cepteurs AMPA, d’o\u00f9 le nom commun du compos\u00e9 – ampakine. L’effet sur ces r\u00e9cepteurs entra\u00eene une augmentation des niveaux du neurotransmetteur glutamate. L’effet ultime de cette action est de stimuler le m\u00e9tabolisme c\u00e9r\u00e9bral et la neuroplasticit\u00e9, c’est-\u00e0-dire la formation de nouvelles connexions neuronales. Certes, l’effet ultime de l’action est d’am\u00e9liorer la fonction cognitive et d’absorber plus facilement les informations.<\/p>\n\n

Un autre m\u00e9canisme d’action du sunifiram est d’augmenter les niveaux d’ac\u00e9tylcholine, le neurotransmetteur responsable de l’efficacit\u00e9 des processus d’apprentissage, de perception ou de m\u00e9moire.<\/p>\n\n

Sunifiram – dosage<\/h2>\n\n

La posologie recommand\u00e9e de l’ampakine est de 5 \u00e0 10 mg par jour. La pr\u00e9paration est \u00e0 prendre de pr\u00e9f\u00e9rence entre les repas, avec beaucoup d’eau.<\/p>\n\n

R\u00e9f\u00e9rences :<\/strong><\/p>\n\n

  1. Romanelli MN et al. \u00ab\u00a0Caract\u00e9risation pharmacologique de DM232 (unifiram) et DM235 (sunifiram), de nouveaux stimulants puissants de la cognition\u00a0\u00bb. CNS Drug Rev. 2006 Spring;12(1):39-52. \n https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6741768\/<\/u>\n<\/a> <\/li>
  2. Moriguchi S, et al, Le sunifiram, nouveau m\u00e9dicament nootrope, am\u00e9liore les d\u00e9ficits cognitifs via l’activation de la CaM kinase II et de la prot\u00e9ine kinase C chez les souris bulbectomis\u00e9es olfactives. Behav Brain Res., 2013 ; \n https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166432812008443<\/u>\n<\/a><\/li>
  3. Ghelardini et al. \u00ab\u00a0DM235 (sunifiram) : un nouveau nootropique avec un potentiel en tant qu’am\u00e9liorateur cognitif\u00a0\u00bb Naunyn-Schmiedeberg’s Arch Pharmacol (2002) 365 : 419. https:\/\/pubmed.ncbi.nlm.nih.gov\/12070754\/<\/u><\/a> <\/li>
  4. Moriguchi S et al. \u00ab\u00a0Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor\u00a0\u00bb. Hippocampe. 2013 Oct;23(10):942-51. \n https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/hipo.22150<\/u>\n<\/a> <\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    Sunifiram N\u00b0 CAS : 314728-85-3 Qu’est-ce que le sunifiram ? Le sunifiram ( 1-benzoyl-4-propanoylpiperazine) est un d\u00e9riv\u00e9 synth\u00e9tique du pirac\u00e9tam, un m\u00e9dicament nootrope. D’autres noms pour la pr\u00e9paration incluent ampakine, DM-235. Il est consid\u00e9r\u00e9 comme l’une des formulations nootropiques les plus puissantes, avec un excellent soutien de la fonction cognitive et une augmentation des niveaux […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162],"tags":[],"class_list":["post-829","post","type-post","status-publish","format-standard","hentry","category-non-classifiee"],"yoast_head":"\nSunifiram - un nootropique pour aider la m\u00e9moire et l'apprentissage<\/title>\n<meta name=\"description\" content=\"Le sunifiram aide \u00e0 l'apprentissage, augmente l'\u00e9nergie et \u00e9limine la fatigue. 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