{"id":772,"date":"2022-10-09T13:20:01","date_gmt":"2022-10-09T13:20:01","guid":{"rendered":"https:\/\/flmodafinil.pl\/sklep\/mebicar-mebicar-temgicoluril-30x-capsules-100mg-purity-%e2%89%a5-99\/"},"modified":"2026-08-13T18:24:00","modified_gmt":"2022-10-29T20:23:57","slug":"mebicar","status":"publish","type":"product","link":"https:\/\/flmodafinil.pl\/en\/sklep\/mebicar\/","title":{"rendered":"Mebicar \/ Temgicoluril: Specification Table for a Tetramethylglycoluril Cage"},"content":{"rendered":"\n\n
Zestawienie parametr\u00f3w materia\u0142u<\/caption>\n
Parameter<\/th>Value<\/th><\/tr><\/thead>\n
Molecular formula<\/td>C8H14N4O2<\/td><\/tr>\n
Formula weight<\/td>198.22 g\/mol<\/td><\/tr>\n
CAS registry number<\/td>10095-06-4<\/td><\/tr>\n
Systematic name<\/td>Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione<\/td><\/tr>\n
Synonyms<\/td>Mebikar, Temgicoluril, tetramethylglycoluril<\/td><\/tr>\n
Scaffold<\/td>Bicyclic glycoluril, a fused bis-ureide, fully N-methylated<\/td><\/tr>\n
Ionisable groups<\/td>None of practical relevance in an ordinary buffer window<\/td><\/tr>\n
Presentation<\/td>Pre-portioned units of 100 mg, per supplier specification<\/td><\/tr>\n<\/tbody>\n<\/table>\n\n\n\n

Reading the scaffold<\/h2>\n\n\n\n

Glycoluril is two urea units fused into a rigid bicyclic cage, and this compound is the derivative in which all four ring nitrogens carry a methyl group. That substitution pattern removes every nitrogen-hydrogen donor from the molecule. The consequence is chemical rather than cosmetic: hydrogen-bond donation disappears, the tight crystal packing that makes unsubstituted glycoluril stubbornly insoluble is disrupted, and the methylated cage gains solubility in water and in polar organic solvents that the parent scaffold does not possess.<\/p>\n\n\n\n

Stability of a fully substituted bis-ureide<\/h2>\n\n\n\n

Cyclic ureas rank among the more hydrolytically robust nitrogen functions in organic chemistry, and a doubly fused, fully methylated one is more robust still. Ring opening calls for forcing acid or base at elevated temperature, not the conditions of ordinary storage or of an aqueous work-up. The realistic failure modes for this material are therefore physical: moisture pickup leading to caking, and cross-contamination carried in on a shared spatula. See also our reagent-grade material: Mebicar \/ Mebicar \/ Temgicoluril – 30x capsules 10<\/a>.<\/p>\n\n\n\n

Analytical handling<\/h2>\n\n\n\n

The molecule has no aromatic ring and no strong chromophore, so ultraviolet detection at the usual wavelengths is a poor tool for purity work. Assay stands on firmer ground with mass spectrometry, with a universal detector such as charged aerosol detection, or with quantitative proton nuclear magnetic resonance against a certified internal standard. The last is convenient here because the four N-methyl groups have no neighbouring protons and appear as clean singlets, which makes identity confirmation a matter of minutes. See also our laboratory reagent: Bleu de m\u00e9thyl\u00e8ne \/ BLEU DE M\u00c9THYL\u00c8NE. Puret\u00e9 \u2265 99<\/a>.<\/p>\n\n\n\n

Storage checklist<\/h2>\n\n\n\n