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Semax

Cas No.: 80714-61-0

What is Semax?

Semax (L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycine) is a peptide that is the terminal fragment of an analog of ACTH, or adrenocorticotropic hormone. Since the compound has an analog structure to compounds found in the body, it therefore works naturally. It was developed by Russian scientists, just like Selank or Ladasten. Available m. in. As a formulation of Cemakc at a concentration of 0.1% and 1%.

The compound is made up of seven amino acids Met-Glu-His-Phe-Pro-Gly-Pro. It differs from the terminal fragment of ACTH by the presence of three amino acids. This translates into better absorption and bioavailability of the product.

Application of Semax

Semax is used to support cognitive function. It perfectly improves concentration, facilitates memorization and processing of information. It will therefore work well for people who work mentally, study and learn. It may find use as an adjunct in the treatment of post-stroke complications or brain injuries that proceed with brain hypoxia. In addition, it can assist in the treatment of disorders such as depressive states and ADHD. The product also shows beneficial effects on the optic nerve, resulting in better visual perception.

Mechanism of action

The product affects areas of the brain crucial for maintaining cognitive function – the hippocampus and forebrain. Its action comes down primarily to increasing the level of brain-derived neurotrophic factor BDNF. It affects serotonergic and cholinergic transmission. Neutralizes free radicals, which translates into reduced oxidative stress and slower neurodegenerative processes.

Semax – dosage

The product is available as a spray applied to the nose. The recommended dosage is 100-150 micrograms, taken intranasally three times a day.

References:

  1. Kirill O. Eremin et al. “Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents” Neurochem Res (2005) 30: 1493; https://pubmed.ncbi.nlm.nih.gov/16362768/
  2. Kost NV et al. “[Semax and selank inhibit the enkephalin-degrading enzymes from human serum].” Bioorg Khim. 2001 May-Jun;27(3):180-3; https://pubmed.ncbi.nlm.nih.gov/11443939/
  3. A. Yatsenko et al. “Heptapeptide Semax Attenuates the Effects of Chronic Unpredictable Stress in Rats” Dokl Biol Sci. 2013 Nov;453:353-7; https://www.semanticscholar.org/paper/Heptapeptide-semax-attenuates-the-effects-of-stress-Yatsenko-Glazova/079d4974ba00a1b251fb8782a563af324f597415
  4. Ekaterina V Medvedeva et al. “The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis” BMC Genomics. 2014; 15: 228; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987924/

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