What is PRL 8-147?
PRL 8-147 is one of the most mysterious nootropics. It’s difficult to actually say “is,” as there is a lack of any official data on this formulation. One can only stumble upon mentions on the Internet. It can be noticed that forums on the subject of nootropic preparations seek information on this unusual preparation, around which legends circulate. It is striking that many people consider it a stronger version of PRL 8-53. This is because it turns out that this is the compound that has been studied more thoroughly and reliable scientific data can be found on the indications for its use and its effectiveness. Here is what is known about him. The PRL 8-53 preparation has been described as one of the most effective memory enhancers. This compound is a derivative of benzoic acid and phenylmethylamine. It was invented and patented in 1970, and has been used in clinical trials for supporting memory, concentration and other cognitive functions.
A 1978 clinical trial that was planned by the discoverer of the PRL 8-53 compound clarified the compound’s action profile. It significantly improved the results in the memory test. Such promising results from the study point to the possible use of PRL 8-53. The product has a nootropic effect, so it can support memory and learning processes. It is primarily dedicated to people who study and work mentally and who need support for brain function. Did a similar operating profile also apply to PRL 8-147? No one knows that. And what is known about this mysterious nootropic?
What is known about PRL 8-147?
It is difficult to find any official mention of the PRL 8-147 formulation. What is known for sure is that in 1970, the discoverer of the human-tested preparation PRL 8-53 registered with the Patent Office: ” A compound selected from a group consisting of m-.[2-(benzyloamino)-etylo] benzamide, m-[2-(benzyloamino)-etylo] Benzoic acid methyl amide, m-.[2-(benzyloamino)-etylo] Benzoic acid benzoate amide, m-.[2-(benzyloamino)-etylo] Benzoic acid diethylamide and m-.[2-(benzyloamino)-etylo] Cyclohexamide benzoic acid or its pharmaceutically acceptable acid salt”. This means, therefore, that several compounds have been researched and patented – and one of them may have just been PRL 8-147.
The mechanism of action of PRL-8-53 has not been conclusively resolved. It is believed that the compound may interact with the cholinergic and dopaminergic systems, thus affecting neurotransmitter transmission. In addition – an increase in dopamine levels is supposed to be accompanied by a simultaneous decrease in serotonin levels. In all likelihood, one can venture to say that the mechanism of action of PRL 8-147 on the body was similar.
References:
- Hansl, N.R., Mead, B.T. PRL-8-53: Enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacology 56, 249-253 (1978); https://link.springer.com/article/10.1007/BF00432846
- Hansl, N.R. A novel spasmolytic and CNS active agent 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride. Experientia 30, 271-272, 1974; https://link.springer.com/article/10.1007/BF01934822
- Hansl NR, Hansl AB Learning and Memory Improvement through Chemistry: Dream or Reality in the Offing? Phi Delta Kappan, 1979;
