Phosphatidylserine
Cas No.: 51446-62-9
What is phosphatidylserine?
Phosphatidylserine is a compound that occurs naturally in the body and is part of cell membranes. The compound is known to be particularly abundant in neurons of the central nervous system. It has a beneficial effect on brain function, affecting transmitter synthesis and nerve transmission. Other names for this compound include Phosphatidylserine, PS, PtdSer.
Phosphatidylserine deficiency in the body is accompanied by deterioration of brain function. This therefore means problems with memory and concentration, greater susceptibility of the body to stress, and chronic fatigue. To prevent this, it is worth supplementing this compound.
The use of phosphatidylserine
Phosphatidylserine is a preparation dedicated to people who study and work mentally, and who need natural brain support. The compound can improve memory and concentration, as well as enhance information processing. This has been confirmed in clinical trials. First, taking 400 mg of phosphatidylserine for just 2 weeks has been shown to significantly improve mental function. Second, it has been proven that in children with ADHD, phosphatidylserine supplementation can alleviate hyperactivity and concentration problems.
The product can increase the synthesis of dopamine and serotonin. This is precisely the effect that has been achieved in patients with Alzheimer’s disease. In addition – it can reduce the rate of cognitive decline.
Mechanism of action
Phosphatidylserine is a compound that maintains optimal fluidity of neuronal cell membranes and ensures proper plasticity of nerve synapses. It is also known to participate in the synthesis of such neurotransmitters as acetylcholine and dopamine. This therefore means more efficient transmission of nerve impulses. Phosphatidylserine improves brain glucose metabolism and ion transport. In addition, the compound can lower cortisol levels, thereby reducing the body’s susceptibility to stress.
Phosphatidylserine – dosage
The recommended dosage of phosphatidylserine is 100-500 mg per day. The most common is 100 mg three times a day. For increased effectiveness, the product can be taken together with acetyl-L-carnitine, CDP-choline or Noopept.
References:
- Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, Jäger R. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. 2014 Apr;27 Suppl 2:284-91; https://pubmed.ncbi.nlm.nih.gov/23495677/
- Manor I, Magen A, Keidar D, Rosen S, Tasker H, Cohen T, Richter Y, Zaaroor-Regev D, Manor Y, Weizman A. The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension. Eur Psychiatry. 2012 Jul;27(5):335-42; https://pubmed.ncbi.nlm.nih.gov/21807480/
- Engel RR, Satzger W, Günther W, Kathmann N, Bove D, Gerke S, Münch U, Hippius H. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol. 1992 Jun;2(2):149-55; https://pubmed.ncbi.nlm.nih.gov/1633433/
- Fünfgeld EW, Baggen M, Nedwidek P, Richstein B, Mistlberger G. Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer’s type (SDAT). Prog Clin Biol Res. 1989;317:1235-46; https://pubmed.ncbi.nlm.nih.gov/2690093/
